|Other Names||Neuropeptide S receptor, G-protein coupled receptor 154, G-protein coupled receptor PGR14, G-protein coupled receptor for asthma susceptibility, NPSR1, GPR154, GPRA, PGR14|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR154, GPRA, PGR14|
|Function||G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.|
|Cellular Location||Isoform 1: Cell membrane; Multi- pass membrane protein Isoform 4: Cell membrane; Multi-pass membrane protein Isoform 5: Cytoplasm Isoform 7: Cytoplasm|
|Tissue Location||Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle cell layer in bronchial and arterial walls (at protein level) (PubMed:15947423). Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients|
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NPSR1 is a member of the G protein-coupled receptor 1family and encodes a plasma membrane protein. Increased expressionof this gene in ciliated cells of the respiratory epithelium and inbronchial smooth muscle cells is associated with asthma.
Raczka, K.A., et al. Mol. Psychiatry 15 (11), 1045 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Donner, J., et al. Biol. Psychiatry 68(5):474-483(2010)Domschke, K., et al. Mol. Psychiatry (2010) In press :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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