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HADH Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16836 |
|---|---|
| Clone Names | 90723050 |
| Gene ID | 3033 |
|---|---|
| Other Names | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, HCDH, Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase, Short-chain 3-hydroxyacyl-CoA dehydrogenase, HADH, HAD, HADHSC, SCHAD |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HADH |
|---|---|
| Function | Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939, PubMed:16725361). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion (By similarity). |
| Cellular Location | Mitochondrion matrix |
| Tissue Location | Expressed in liver, kidney, pancreas, heart and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the 3-hydroxyacyl-CoAdehydrogenase gene family. The encoded protein functions in themitochondrial matrix to catalyze the oxidation of straight-chain3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Itsenzymatic activity is highest with medium-chain-length fatty acids.Mutations in this gene cause one form of familial hyperinsulinemichypoglycemia. The human genome contains a related pseudogene ofthis gene on chromosome 15.
References
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Di Candia, S., et al. Eur. J. Endocrinol. 160(6):1019-1023(2009)van Hove, E.C., et al. Diabetes 55(11):3193-3196(2006)Yang, S.Y., et al. FEBS J. 272(19):4874-4883(2005)Vredendaal, P.J., et al. Mamm. Genome 9(9):763-768(1998)
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