|Other Names||Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial, HCDH, Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase, Short-chain 3-hydroxyacyl-CoA dehydrogenase, HADH, HAD, HADHSC, SCHAD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HAD, HADHSC, SCHAD|
|Function||Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Expressed in liver, kidney, pancreas, heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the 3-hydroxyacyl-CoAdehydrogenase gene family. The encoded protein functions in themitochondrial matrix to catalyze the oxidation of straight-chain3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Itsenzymatic activity is highest with medium-chain-length fatty acids.Mutations in this gene cause one form of familial hyperinsulinemichypoglycemia. The human genome contains a related pseudogene ofthis gene on chromosome 15.
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Di Candia, S., et al. Eur. J. Endocrinol. 160(6):1019-1023(2009)van Hove, E.C., et al. Diabetes 55(11):3193-3196(2006)Yang, S.Y., et al. FEBS J. 272(19):4874-4883(2005)Vredendaal, P.J., et al. Mamm. Genome 9(9):763-768(1998)
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