|Other Names||Collagen alpha-1(XVIII) chain, Endostatin, COL18A1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Present in multiple organs with highest levels in liver, lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
COL18A1 is the alpha chain of type XVIII collagen.This collagen is one of the multiplexins, extracellular matrixproteins that contain multiple triple-helix domains (collagenousdomains) interrupted by non-collagenous domains. Theproteolytically produced C-terminal fragment of type XVIII collagenis endostatin, a potent antiangiogenic protein. Mutations in thisgene are associated with Knobloch syndrome. The main features ofthis syndrome involve retinal abnormalities, so type XVIII collagenmay play an important role in retinal structure and in neural tubeclosure.
Hamano, Y., et al. J. Am. Soc. Nephrol. 21(9):1445-1455(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Lee, K.S., et al. Tumour Biol. 31(3):165-170(2010)Faye, C., et al. Biochem. J. 427(3):467-475(2010)Polikarpova, S.B., et al. Bull. Exp. Biol. Med. 148(4):634-637(2009)
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