|Other Names||F-box/WD repeat-containing protein 8, F-box and WD-40 domain-containing protein 8, F-box only protein 29, FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||FBW6, FBW8, FBX29, FBXO29, FBXW6|
|Function||Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695).|
|Cellular Location||Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the F-box protein family,members of which are characterized by an approximately 40 aminoacid motif, the F-box. The F-box proteins constitute one of thefour subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependentubiquitination. The F-box proteins are divided into three classes:Fbws containing WD-40 domains, Fbls containing leucine-richrepeats, and Fbxs containing either different protein-proteininteraction modules or no recognizable motifs. The protein encodedby this gene contains a WD-40 domain, in addition to an F-boxmotif, so it belongs to the Fbw class. Alternatively splicedtranscript variants encoding distinct isoforms have been identifiedfor this gene.
Tsutsumi, T., et al. Mol. Cell. Biol. 28(2):743-751(2008)Koch, H.B., et al. Cell Cycle 6(2):205-217(2007)Okabe, H., et al. PLoS ONE 1, E128 (2006) :Watanabe, N., et al. Proc. Natl. Acad. Sci. U.S.A. 101(13):4419-4424(2004)Dias, D.C., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16601-16606(2002)
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