|Other Names||Glycerol-3-phosphate dehydrogenase 1-like protein, GPD1-L, GPD1L, KIAA0089|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.|
|Cellular Location||Cytoplasm. Note=Localized to the region of the plasma membrane|
|Tissue Location||Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the conversionof sn-glycerol 3-phosphate to glycerone phosphate. The encodedprotein is found in the cytoplasm, associated with the plasmamembrane, where it binds the sodium channel, voltage-gated, type V,alpha subunit (SCN5A). Defects in this gene are a cause of Brugadasyndrome type 2 (BRS2) as well as sudden infant death syndrome(SIDS).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Liu, M., et al. Circ. Res. 105(8):737-745(2009)Valdivia, C.R., et al. Am. J. Physiol. Heart Circ. Physiol. 297 (4), H1446-H1452 (2009) :Makiyama, T., et al. Circ. J. 72(10):1705-1706(2008)London, B., et al. Circulation 116(20):2260-2268(2007)
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