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TMEM66 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96BY9
Clone Names 91102089
Peptide ID 91102089
Additional Information
Gene ID 51669
Other Names Store-operated calcium entry-associated regulatory factor, SARAF, SOCE-associated regulatory factor, HBV X-transactivated gene 3 protein, HBV XAg-transactivated protein 3, Protein FOAP-7, Transmembrane protein 66, SARAF, TMEM66, XTP3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TMEM66, XTP3
Function Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1- dependent manner following cytosolic Ca(2+) elevation
Tissue Location Highly expressed in macrophages. {ECO:0000269|Ref.2}
Research Areas
Citations (0)

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TMEM66 is a multi-pass membrane protein which belongs to the TMEM66 family. The exact function of TMEM66 remains unknown.


Rose, J. Phd, et al. Mol. Med. (2010) In press :Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 80.00
Cat# BP10746a
Availability: In Stock
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