|Other Names||Retinol dehydrogenase 12, 111-, All-trans and 9-cis retinol dehydrogenase, RDH12|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments.|
|Tissue Location||Widely expressed, mostly in eye, kidney, brain, skeletal muscle and stomach|
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The protein encoded by this gene is an NADPH-dependentretinal reductase whose highest activity is toward 9-cis andall-trans-retinol. The encoded enzyme also plays a role in themetabolism of short-chain aldehydes but does not exhibit steroiddehydrogenase activity. Defects in this gene are a cause of Lebercongenital amaurosis type 3 (LCA3).
Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)Lee, S.A., et al. FEBS Lett. 584(3):507-510(2010)Marchette, L.D., et al. Free Radic. Biol. Med. 48(1):16-25(2010)Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :Sundaresan, P., et al. Mol. Vis. 15, 1781-1787 (2009) :
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