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CLLD8/SETDB2 Antibody (Center V514) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q96T68
Clone Names 4020610
Additional Information
Gene ID 83852
Other Names Histone-lysine N-methyltransferase SETDB2, Chronic lymphocytic leukemia deletion region gene 8 protein, Lysine N-methyltransferase 1F, SET domain bifurcated 2, SETDB2, C13orf4, CLLD8, KMT1F
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1075b was selected from the Center region of human SETDB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C13orf4, CLLD8, KMT1F
Function Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Cellular Location Nucleus. Chromosome
Tissue Location Ubiquitous. Highest expression in heart, testis and ovary
Research Areas
Citations (0)

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Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity.


Zhang, Y., et al., Nat. Genet. 34(2):181-186 (2003).Mabuchi, H., et al., Cancer Res. 61(7):2870-2877 (2001).

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$ 80.00
Cat# BP1075b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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