|Other Names||Ribonuclease T2, 3127-, Ribonuclease 6, RNASET2, RNASE6PL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.|
|Cellular Location||Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction|
|Tissue Location||Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
This ribonuclease gene is a novel member of theRh/T2/S-glycoprotein class of extracellular ribonucleases. It is asingle copy gene that maps to 6q27, a region associated with humanmalignancies and chromosomal rearrangement.
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)Quan, C., et al. Nat. Genet. 42(7):614-618(2010)Liu, J., et al. J. Cell. Mol. Med. 14(5):1146-1155(2010)Henneke, M., et al. Nat. Genet. 41(7):773-775(2009)Monti, L., et al. Oncol. Res. 17(2):69-74(2008)
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