RNT2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O00584 |
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Clone Names | 91109316 |
Gene ID | 8635 |
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Other Names | Ribonuclease T2, 3127-, Ribonuclease 6, RNASET2, RNASE6PL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RNASET2 |
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Synonyms | RNASE6PL |
Function | Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 (PubMed:31778653). Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides (PubMed:31778653). In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 (PubMed:31778653). Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria (PubMed:28730546, PubMed:30184494). Participates as well in degradation of mitochondrion-associated cytosolic rRNAs (PubMed:30385512). |
Cellular Location | Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Mitochondrion intermembrane space. Note=Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction. |
Tissue Location | Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This ribonuclease gene is a novel member of theRh/T2/S-glycoprotein class of extracellular ribonucleases. It is asingle copy gene that maps to 6q27, a region associated with humanmalignancies and chromosomal rearrangement.
References
Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)Quan, C., et al. Nat. Genet. 42(7):614-618(2010)Liu, J., et al. J. Cell. Mol. Med. 14(5):1146-1155(2010)Henneke, M., et al. Nat. Genet. 41(7):773-775(2009)Monti, L., et al. Oncol. Res. 17(2):69-74(2008)
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