|Other Names||Reticulon-4-interacting protein 1, mitochondrial, NOGO-interacting mitochondrial protein, RTN4IP1, NIMP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.|
|Cellular Location||Mitochondrion outer membrane Note=Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria|
|Tissue Location||Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.|
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This gene encodes a novel mitochondrial protein thatinteracts with reticulon 4, which is a potent inhibitor ofregeneration following spinal cord injury. The interaction ofreticulon 4 with mitochondrial proteins may provide insight intothe mechanisms for reticulon-induced inhibition of neurite growth.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Mungall, A.J., et al. Nature 425(6960):805-811(2003)Domeniconi, M., et al. Neuron 35(2):283-290(2002)Hu, W.H., et al. J. Neurochem. 81(1):36-45(2002)
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