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CB086 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95876 |
|---|---|
| Clone Names | 91201024 |
| Gene ID | 51057 |
|---|---|
| Other Names | WD repeat-containing and planar cell polarity effector protein fritz homolog, hFRTZ, Bardet-Biedl syndrome 15 protein, WD repeat-containing and planar cell polarity effector protein, WDPCP, BBS15, C2orf86, FRITZ |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | WDPCP |
|---|---|
| Synonyms | BBS15, C2orf86, FRITZ |
| Function | Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q32NR9}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q32NR9} Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q32NR9} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The C2ORF86 gene encodes an ortholog of Drosophila'fritz,' a cytoplasmic WD40 repeat protein that controls planarcell polarity (summarized by Kim et al., 2010 [PubMed20671153]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, S.K., et al. Science 329(5997):1337-1340(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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