|Other Names||WD repeat-containing and planar cell polarity effector protein fritz homolog, hFRTZ, Bardet-Biedl syndrome 15 protein, WD repeat-containing and planar cell polarity effector protein, WDPCP, BBS15, C2orf86, FRITZ|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||BBS15, C2orf86, FRITZ|
|Function||Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements.|
|Cellular Location||Cell membrane. Cytoplasm, cytoskeleton, cilium axoneme|
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Provided below are standard protocols that you may find useful for product applications.
The C2ORF86 gene encodes an ortholog of Drosophila'fritz,' a cytoplasmic WD40 repeat protein that controls planarcell polarity (summarized by Kim et al., 2010 [PubMed20671153]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Kim, S.K., et al. Science 329(5997):1337-1340(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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