|Other Names||Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1078b was selected from the C-term region of human GCN5L2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GCN5, GCN5L2, HGCN5|
|Function||Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Also acetylates non- histone proteins, such as CEBPB (PubMed:17301242). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.|
|Tissue Location||Expressed in all tissues tested, with most abundant expression in ovary|
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Provided below are standard protocols that you may find useful for product applications.
GCN5L2 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. This protein has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles
Kikuchi, H., et al., Gene 347(1):83-97 (2005).Gangisetty, O., et al., Oncogene 23(14):2559-2563 (2004).Lusic, M., et al., EMBO J. 22(24):6550-6561 (2003).Fulco, M., et al., Mol. Cell 12(1):51-62 (2003).Liu, X., et al., J. Biol. Chem. 278(22):20405-20412 (2003).
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