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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   GCN5 (GCN5L2) Antibody (C-term) Blocking peptide   

GCN5 (GCN5L2) Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q92830
Other Accession Q8N1A2
Clone Names 4020626
Peptide ID 4020626
Additional Information
Gene ID 2648
Other Names Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1078b was selected from the C-term region of human GCN5L2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT2A
Synonyms GCN5, GCN5L2, HGCN5
Function Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Cellular Location Nucleus.
Tissue Location Expressed in all tissues tested, with most abundant expression in ovary
Research Areas
Citations (0)

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Background

GCN5L2 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. This protein has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles

References

Kikuchi, H., et al., Gene 347(1):83-97 (2005).Gangisetty, O., et al., Oncogene 23(14):2559-2563 (2004).Lusic, M., et al., EMBO J. 22(24):6550-6561 (2003).Fulco, M., et al., Mol. Cell 12(1):51-62 (2003).Liu, X., et al., J. Biol. Chem. 278(22):20405-20412 (2003).

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$ 80.00
Cat# BP1078b
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