|Other Names||La-related protein 6, Acheron, Achn, La ribonucleoprotein domain family member 6, LARP6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm|
|Tissue Location||Expressed in numerous tissues.|
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Provided below are standard protocols that you may find useful for product applications.
LARP6 is a member of the La ribonucleoprotein domain family, which all contain one characteristic La motif. LARP6 shuttles between the cytoplasm and nucleus. It is proposed that members of this family play a role in translation and mRNA stability.
Cai, L., et al. J. Mol. Biol. 395(2):309-326(2010)Glenn, H.L., et al. Am. J. Physiol., Cell Physiol. 298 (1), C46-C55 (2010) :Valavanis, C., et al. Gene 393 (1-2), 101-109 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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