|Other Names||CD2 antigen cytoplasmic tail-binding protein 2, CD2 cytoplasmic domain-binding protein 2, CD2 tail-binding protein 2, U5 snRNP 52K protein, U5-52K, CD2BP2, KIAA1178|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly nuclear|
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This gene encodes a bi-functional protein. In thecytoplasm, the encoded protein binds the cytoplasmic tail of humansurface antigen CD2 via its C-terminal GYF domain, and regulateCD2-triggered T lymphocyte activation. In the nucleus, this proteinis a component of the U5 small nuclear ribonucleoprotein complexand is involved in RNA splicing. A pseudogene has been identifiedon chromosome 7. Alternative splicing results in multipletranscript variants but their biological validity has not beendetermined.
Heinze, M., et al. Int. Immunol. 19(11):1313-1318(2007)Nielsen, T.K., et al. J. Mol. Biol. 369(4):902-908(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)Al-Dhaheri, M.H., et al. Steroids 71 (11-12), 966-978 (2006) :
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