|Other Names||Interleukin-18, IL-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, IL18, IGIF, IL1F4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a proinflammatorycytokine. This cytokine can induce the IFN-gamma production of Tcells. The combination of this cytokine and IL12 has been shown toinhibit IL4 dependent IgE and IgG1 production, and enhance IgG2aproduction of B cells. IL-18 binding protein (IL18BP) canspecifically interact with this cytokine, and thus negativelyregulate its biological activity.
Hernesniemi, J.A., et al. Eur. J. Clin. Invest. 40(11):994-1001(2010)Hartford, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(10):2039-2046(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Franchim, C.S., et al. Hypertens Pregnancy (2010) In press :Ayaz, L., et al. Fertil. Steril. (2010) In press :
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