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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q4KWH8 |
|---|---|
| Clone Names | 91113210 |
| Peptide ID | 91113210 |
| Gene ID | 23007 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase eta-1, Phosphoinositide phospholipase C-eta-1, Phospholipase C-eta-1, PLC-eta-1, Phospholipase C-like protein 3, PLC-L3, PLCH1, KIAA1069, PLCL3 |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLCH1 |
|---|---|
| Synonyms | KIAA1069, PLCL3 |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. |
| Cellular Location | Cytoplasm. Membrane |
| Tissue Location | Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PLCH1 is a member of the PLC-eta family of thephosphoinositide-specific phospholipase C (PLC) superfamily ofenzymes that cleave phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2) to generate second messengers inositol1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al.,2005 [PubMed 15702972]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hwang, J.I., et al. Biochem. J. 389 (PT 1), 181-186 (2005) :Stewart, A.J., et al. Int. J. Mol. Med. 15(1):117-121(2005)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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