|Other Names||1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase eta-1, Phosphoinositide phospholipase C-eta-1, Phospholipase C-eta-1, PLC-eta-1, Phospholipase C-like protein 3, PLC-L3, PLCH1, KIAA1069, PLCL3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.|
|Cellular Location||Cytoplasm. Membrane|
|Tissue Location||Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
PLCH1 is a member of the PLC-eta family of thephosphoinositide-specific phospholipase C (PLC) superfamily ofenzymes that cleave phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2) to generate second messengers inositol1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al.,2005 [PubMed 15702972]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hwang, J.I., et al. Biochem. J. 389 (PT 1), 181-186 (2005) :Stewart, A.J., et al. Int. J. Mol. Med. 15(1):117-121(2005)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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