Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
PLCH1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q4KWH8 |
|---|---|
| Clone Names | 91113210 |
| Gene ID | 23007 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase eta-1, Phosphoinositide phospholipase C-eta-1, Phospholipase C-eta-1, PLC-eta-1, Phospholipase C-like protein 3, PLC-L3, PLCH1, KIAA1069, PLCL3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PLCH1 (HGNC:29185) |
|---|---|
| Synonyms | KIAA1069, PLCL3 |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes. |
| Cellular Location | Cytoplasm. Membrane |
| Tissue Location | Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord. In embryo expressed in the notochord, developing spinal cord (in a ventral to dorsal gradient), dorsal root ganglia, cerebellum and dermatomyosome. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
PLCH1 is a member of the PLC-eta family of thephosphoinositide-specific phospholipase C (PLC) superfamily ofenzymes that cleave phosphatidylinositol 4,5-bisphosphate(PtdIns(4,5)P2) to generate second messengers inositol1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al.,2005 [PubMed 15702972]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Hwang, J.I., et al. Biochem. J. 389 (PT 1), 181-186 (2005) :Stewart, A.J., et al. Int. J. Mol. Med. 15(1):117-121(2005)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
