|Other Names||Protein phosphatase 1L, Protein phosphatase 1-like, Protein phosphatase 2C isoform epsilon, PP2C-epsilon, PPM1L, PP2CE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
PPM1L, or PP2CE, belongs to the PP2C group ofserine/threonine phosphatases, which are distinguished from otherphosphatases by their structure, absolute requirement for Mg(2+) orMn(2+), and insensitivity to okadaic acid. PP2Cs regulatestress-activated protein kinase (SAPK; see MIM 601158) signalingcascades that respond to extracellular stimuli (Jin et al., 2004[PubMed 15560375]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Thean, L.F., et al. Genes Chromosomes Cancer 49(2):99-106(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Saito, S., et al. J. Biol. Chem. 283(10):6584-6593(2008)Saito, J., et al. Biochem. J. 405(3):591-596(2007)
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