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FZD6 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O60353
Clone Names 91009140
Peptide ID 91009140
Additional Information
Gene ID 8323
Other Names Frizzled-6, Fz-6, hFz6, FZD6
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD6
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
Cellular Location Membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein. Cell surface {ECO:0000250|UniProtKB:Q61089}. Apical cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q61089}; Multi-pass membrane protein. Note=Colocalizes with FZD3 at the apical face of cells (By similarity) {ECO:0000250|UniProtKB:Q61089}
Tissue Location Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney
Research Areas
Citations (0)

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This gene represents a member of the 'frizzled' genefamily, which encode 7-transmembrane domain proteins that arereceptors for Wnt signaling proteins. The protein encoded by thisfamily member contains a signal peptide, a cysteine-rich domain inthe N-terminal extracellular region, and seven transmembranedomains, but unlike other family members, this protein does notcontain a C-terminal PDZ domain-binding motif. This proteinfunctions as a negative regulator of the canonical Wnt/beta-cateninsignaling cascade, thereby inhibiting the processes that triggeroncogenic transformation, cell proliferation, and inhibition ofapoptosis. Alternative splicing results in multiple transcriptvariants.


Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Kim, J.G., et al. J. Korean Med. Sci. 24(3):443-447(2009)Miyakoshi, T., et al. Endocr. Pathol. 19(4):261-273(2008)Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007)Lyons, J.P., et al. Exp. Cell Res. 298(2):369-387(2004)

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$ 80.00
Cat# BP11009c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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