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BCDO2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BYV7 |
|---|---|
| Clone Names | 91201015 |
| Gene ID | 83875 |
|---|---|
| Other Names | Beta, beta-carotene 9', 10'-oxygenase, B-diox-II, Beta-carotene dioxygenase 2, BCO2, BCDO2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BCO2 (HGNC:18503) |
|---|---|
| Function | Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon- carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules. |
| Cellular Location | Mitochondrion {ECO:0000250|UniProtKB:Q99NF1}. |
| Tissue Location | Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
BCDO2 catalyzes the asymmetric oxidative cleavage ofbeta-carotene in carotene metabolism (Kiefer et al., 2001 [PubMed11278918]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)He, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(4):885-890(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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