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AIRE Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O43918
Clone Names 90713006
Peptide ID 90713006
Additional Information
Gene ID 326
Other Names Autoimmune regulator, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, APECED protein, AIRE, APECED
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms APECED
Function Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions.
Cellular Location Nucleus. Cytoplasm. Note=Associated with tubular structures and in discrete nuclear dots resembling ND10 nuclear bodies. May shuttle between nucleus and cytoplasm
Tissue Location Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all
Research Areas
Citations (0)

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This gene encodes a transcriptional regulator that formsnuclear bodies and interacts with the transcriptional coactivatorCBP. At least three splice variant mRNAs products have beendescribed including one which results in a premature stop codon anda transcript predicted to be a candidate for nuclear-mediated decay(NMD). Defects in this gene cause the rare autosomal-recessivesystemic autoimmune disease termed autoimmunepolyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).


Cervato, S., et al. Clin. Endocrinol. (Oxf) 73(5):630-636(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Conteduca, G., et al. Clin. Immunol. 136(1):96-104(2010)Colome, N., et al. J. Proteome Res. 9(5):2600-2609(2010)Gu, B., et al. Biochem. Biophys. Res. Commun. 394(2):418-423(2010)

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$ 80.00
Cat# BP11079c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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