|Other Names||Cytochrome P450 2B6, 11413-, 4-cineole 2-exo-monooxygenase, CYPIIB6, Cytochrome P450 IIB1, CYP2B6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Expressed in liver, lung and heart right ventricle.|
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This gene, CYP2B6, encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and itsexpression is induced by phenobarbital. The enzyme is known tometabolize some xenobiotics, such as the anti-cancer drugscyclophosphamide and ifosphamide. Transcript variants for this genehave been described; however, it has not been resolved whetherthese transcripts are in fact produced by this gene or by a closelyrelated pseudogene, CYP2B7. Both the gene and the pseudogene arelocated in the middle of a CYP2A pseudogene found in a largecluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2Fsubfamilies on chromosome 19q.
Figueroa, S.C., et al. Ther Drug Monit 32(5):579-585(2010)Chou, M., et al. Antimicrob. Agents Chemother. 54(10):4432-4439(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bunten, H., et al. Clin. Pharmacol. Ther. 88(3):383-389(2010)Gounden, V., et al. AIDS Res Ther 7, 32 (2010) :
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