|Other Names||CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a, CNOT7, CAF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity.|
|Cellular Location||Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body.|
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The protein encoded by this gene binds to ananti-proliferative protein, B-cell translocation protein 1, whichnegatively regulates cell proliferation. Binding of the twoproteins, which is driven by phosphorylation of theanti-proliferative protein, causes signaling events in celldivision that lead to changes in cell proliferation associated withcell-cell contact. The protein has both mouse and yeast orthologs.Alternate splicing of this gene results in two transcript variantsencoding different isoforms.
Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)Aslam, A., et al. Mol. Biol. Cell 20(17):3840-3850(2009)Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)Nishida, K., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (PT 12), 1061-1063 (2007) :Robin-Lespinasse, Y., et al. J. Cell. Sci. 120 (PT 4), 638-647 (2007) :
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