|Other Names||Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, Homeoprotein LFB3, Transcription factor 2, TCF-2, Variant hepatic nuclear factor 1, vHNF1, HNF1B, TCF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.|
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This gene encodes a member of the homeodomain-containingsuperfamily of transcription factors. The protein binds to DNA aseither a homodimer, or a heterodimer with the related proteinhepatocyte nuclear factor 1-alpha. The gene has been shown tofunction in nephron development, and regulates development of theembryonic pancreas. Mutations in this gene result in renal cystsand diabetes syndrome and noninsulin-dependent diabetes mellitus,and expression of this gene is altered in some types of cancer.Multiple transcript variants encoding different isoforms have beenfound for this gene.
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Oram, R.A., et al. Am. J. Obstet. Gynecol. 203 (4), 364 (2010) :Takata, R., et al. Nat. Genet. 42(9):751-754(2010)Liu, H., et al. Prostate (2010) In press :Maestro, M.A., et al. Endocr Dev 12, 33-45 (2007) :
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