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HNF1B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P35680 |
|---|---|
| Clone Names | 80513008 |
| Gene ID | 6928 |
|---|---|
| Other Names | Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, Homeoprotein LFB3, Transcription factor 2, TCF-2, Variant hepatic nuclear factor 1, vHNF1, HNF1B, TCF2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HNF1B |
|---|---|
| Synonyms | TCF2 |
| Function | Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:7900999, PubMed:17924661). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the homeodomain-containingsuperfamily of transcription factors. The protein binds to DNA aseither a homodimer, or a heterodimer with the related proteinhepatocyte nuclear factor 1-alpha. The gene has been shown tofunction in nephron development, and regulates development of theembryonic pancreas. Mutations in this gene result in renal cystsand diabetes syndrome and noninsulin-dependent diabetes mellitus,and expression of this gene is altered in some types of cancer.Multiple transcript variants encoding different isoforms have beenfound for this gene.
References
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Oram, R.A., et al. Am. J. Obstet. Gynecol. 203 (4), 364 (2010) :Takata, R., et al. Nat. Genet. 42(9):751-754(2010)Liu, H., et al. Prostate (2010) In press :Maestro, M.A., et al. Endocr Dev 12, 33-45 (2007) :
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