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EMG1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92979 |
|---|---|
| Clone Names | 90909044 |
| Gene ID | 10436 |
|---|---|
| Other Names | Ribosomal RNA small subunit methyltransferase NEP1, 211-, 18S rRNA (pseudouridine(1248)-N1)-methyltransferase, 18S rRNA Psi1248 methyltransferase, Nucleolar protein EMG1 homolog, Protein C2f, Ribosome biogenesis protein NEP1, EMG1 {ECO:0000303|PubMed:19463982} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EMG1 {ECO:0000303|PubMed:19463982} |
|---|---|
| Function | S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). |
| Cellular Location | Nucleus, nucleolus |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an essential, conserved eukaryoticprotein involved in ribosome biogenesis. In yeast, the relatedprotein is a component of the small subunit processome and isessential for biogenesis of the ribosomal 40S subunit. A mutationin this gene has been associated with Bowen-Conradi syndrome.
References
Armistead, J., et al. Am. J. Hum. Genet. 84(6):728-739(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Lamont, R.E., et al. Am. J. Med. Genet. A 132A (2), 136-143 (2005) :Bernstein, K.A., et al. Eukaryotic Cell 3(6):1619-1626(2004)Eschrich, D., et al. Curr. Genet. 40(5):326-338(2002)
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