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RNF19B Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6ZMZ0 |
|---|---|
| Clone Names | 91216019 |
| Gene ID | 127544 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase RNF19B, 632-, IBR domain-containing protein 3, Natural killer lytic-associated molecule, RING finger protein 19B, RNF19B, IBRDC3, NKLAM |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RNF19B |
|---|---|
| Synonyms | IBRDC3, NKLAM |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036). |
| Cellular Location | Cytoplasmic granule membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells (PubMed:10438909). Present in natural killer cells (at protein level) (PubMed:10912506) Ubiquitously expressed with high expression in testis (PubMed:27485036). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
IBRDC3 is a cytolysis-associated transmembrane proteinexpressed in natural killer (NK) cells and T lymphocytes followingcytokine stimulation (Kozlowski et al., 1999 [PubMed10438909]).
References
Fortier, J.M., et al. J. Immunol. 176(11):6454-6463(2006)Kozlowski, M., et al. J. Immunol. 163(4):1775-1785(1999)
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