|Other Names||FAD-linked sulfhydryl oxidase ALR, Augmenter of liver regeneration, hERV1, Hepatopoietin, GFER, ALR, HERV1, HPO|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ALR, HERV1, HPO|
|Function||Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.|
|Cellular Location||Isoform 1: Mitochondrion intermembrane space|
|Tissue Location||Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle|
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The hepatotrophic factor designated augmenter of liverregeneration (ALR) is thought to be one of the factors responsiblefor the extraordinary regenerative capacity of mammalian liver. Ithas also been called hepatic regenerative stimulation substance(HSS). The gene resides on chromosome 16 in the interval containingthe locus for polycystic kidney disease (PKD1). The putative geneproduct is 42% similar to the scERV1 protein of yeast. The yeastscERV1 gene had been found to be essential for oxidativephosphorylation, the maintenance of mitochondrial genomes, and thecell division cycle. The human gene is both the structural andfunctional homolog of the yeast scERV1 gene.
Dong, L.Y., et al. Biochem. J. 431(2):277-287(2010)Li, W., et al. FEBS Lett. 584(18):3929-3935(2010)Daithankar, V.N., et al. Biochemistry 49(31):6737-6745(2010)Dayoub, R., et al. Biochem. Biophys. Res. Commun. 395(4):465-470(2010)Chang, J., et al. World J. Gastroenterol. 16(2):193-200(2010)
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