TIMP1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P01033 |
---|---|
Clone Names | 71213150 |
Gene ID | 7076 |
---|---|
Other Names | Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TIMP1 |
---|---|
Synonyms | CLGI, TIMP |
Function | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. |
Cellular Location | Secreted |
Tissue Location | Detected in rheumatoid synovial fluid (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene belongs to the TIMP gene family. The proteinsencoded by this gene family are natural inhibitors of the matrixmetalloproteinases (MMPs), a group of peptidases involved indegradation of the extracellular matrix. In addition to itsinhibitory role against most of the known MMPs, the encoded proteinis able to promote cell proliferation in a wide range of celltypes, and may also have an anti-apoptotic function. Transcriptionof this gene is highly inducible in response to many cytokines andhormones. In addition, the expression from some but not allinactive X chromosomes suggests that this gene inactivation ispolymorphic in human females. This gene is located within intron 6of the synapsin I gene and is transcribed in the oppositedirection.
References
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lin, C.C., et al. Clin J Am Soc Nephrol 5(10):1805-1814(2010)Yeh, Y.C., et al. BMC Microbiol. 10, 218 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.