|Other Names||Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.|
|Tissue Location||Detected in rheumatoid synovial fluid (at protein level).|
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This gene belongs to the TIMP gene family. The proteinsencoded by this gene family are natural inhibitors of the matrixmetalloproteinases (MMPs), a group of peptidases involved indegradation of the extracellular matrix. In addition to itsinhibitory role against most of the known MMPs, the encoded proteinis able to promote cell proliferation in a wide range of celltypes, and may also have an anti-apoptotic function. Transcriptionof this gene is highly inducible in response to many cytokines andhormones. In addition, the expression from some but not allinactive X chromosomes suggests that this gene inactivation ispolymorphic in human females. This gene is located within intron 6of the synapsin I gene and is transcribed in the oppositedirection.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lin, C.C., et al. Clin J Am Soc Nephrol 5(10):1805-1814(2010)Yeh, Y.C., et al. BMC Microbiol. 10, 218 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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