|Other Names||Histidine--tRNA ligase, cytoplasmic, Histidyl-tRNA synthetase, HisRS, HARS, HRS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance.|
|Tissue Location||Brain, heart, liver and kidney.|
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Aminoacyl-tRNA synthetases are a class of enzymes thatcharge tRNAs with their cognate amino acids. The protein encoded bythis gene is a cytoplasmic enzyme which belongs to the class IIfamily of aminoacyl-tRNA synthetases. The enzyme is responsible forthe synthesis of histidyl-transfer RNA, which is essential for theincorporation of histidine into proteins. The gene is located in ahead-to-head orientation with HARSL on chromosome five, where thehomologous genes share a bidirectional promoter. The gene productis a frequent target of autoantibodies in the human autoimmunedisease polymyositis/dermatomyositis.
Gomard-Mennesson, E., et al. Ann. N. Y. Acad. Sci. 1109, 414-420 (2007) :Levine, S.M., et al. Arthritis Rheum. 56(8):2729-2739(2007)Lu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 100(13):7626-7631(2003)Ascherman, D.P., et al. J. Immunol. 169(12):7127-7134(2002)O'Hanlon, T.P., et al. Biochem. Biophys. Res. Commun. 294(3):609-614(2002)
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