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HARS Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P12081 |
|---|---|
| Clone Names | 71228118 |
| Gene ID | 3035 |
|---|---|
| Other Names | Histidine--tRNA ligase, cytoplasmic, Histidyl-tRNA synthetase, HisRS, HARS, HRS |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HARS1 (HGNC:4816) |
|---|---|
| Synonyms | HARS, HRS |
| Function | Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:F1Q5D5}. |
| Tissue Location | Brain, heart, liver and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aminoacyl-tRNA synthetases are a class of enzymes thatcharge tRNAs with their cognate amino acids. The protein encoded bythis gene is a cytoplasmic enzyme which belongs to the class IIfamily of aminoacyl-tRNA synthetases. The enzyme is responsible forthe synthesis of histidyl-transfer RNA, which is essential for theincorporation of histidine into proteins. The gene is located in ahead-to-head orientation with HARSL on chromosome five, where thehomologous genes share a bidirectional promoter. The gene productis a frequent target of autoantibodies in the human autoimmunedisease polymyositis/dermatomyositis.
References
Gomard-Mennesson, E., et al. Ann. N. Y. Acad. Sci. 1109, 414-420 (2007) :Levine, S.M., et al. Arthritis Rheum. 56(8):2729-2739(2007)Lu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 100(13):7626-7631(2003)Ascherman, D.P., et al. J. Immunol. 169(12):7127-7134(2002)O'Hanlon, T.P., et al. Biochem. Biophys. Res. Commun. 294(3):609-614(2002)
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