|Other Names||Leucine--tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase, LeuRS, LARS, KIAA1352|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic leucine-tRNA synthetase, amember of the class I aminoacyl-tRNA synthetase family. The encodedenzyme catalyzes the ATP-dependent ligation of L-leucine totRNA(Leu). It is found in the cytoplasm as part of amultisynthetase complex and interacts with the arginine tRNAsynthetase through its C-terminal domain. Alternatively splicedtranscript variants of this gene have been found; however, theirfull-length nature is not known.
Pang, Y.L., et al. Biochemistry 48(38):8958-8964(2009)Seiradake, E., et al. J. Mol. Biol. 390(2):196-207(2009)Shin, S.H., et al. Exp. Mol. Med. 40(2):229-236(2008)Maeso, E., et al. Neuromuscul. Disord. 17(5):415-418(2007)Lue, S.W., et al. Biochemistry 46(15):4466-4472(2007)
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