|Other Names||Translation initiation factor eIF-2B subunit delta, eIF-2B GDP-GTP exchange factor subunit delta, EIF2B4, EIF2BD|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|
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Provided below are standard protocols that you may find useful for product applications.
Eukaryotic initiation factor 2B (EIF2B), which isnecessary for protein synthesis, is a GTP exchange factor composedof five different subunits. The protein encoded by this gene is thefourth, or delta, subunit. Defects in this gene are a cause ofleukoencephalopathy with vanishing white matter (VWM) andovarioleukodystrophy. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Naukkarinen, J., et al. PLoS Genet. 6 (6), E1000976 (2010) :Wu, Y., et al. J. Hum. Genet. 54(2):74-77(2009)Horzinski, L., et al. PLoS ONE 4 (12), E8318 (2009) :Pronk, J., et al. Mult. Scler. 14(8):1123-1126(2008)Wong, S.S., et al. J. Child Neurol. 23(6):710-714(2008)
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