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EIF2B4 Antibody (Center K161) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UI10 |
|---|---|
| Clone Names | 80703067 |
| Gene ID | 8890 |
|---|---|
| Other Names | Translation initiation factor eIF-2B subunit delta, eIF-2B GDP-GTP exchange factor subunit delta, EIF2B4, EIF2BD |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | EIF2B4 |
|---|---|
| Synonyms | EIF2BD |
| Function | Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl- initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09924} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Eukaryotic initiation factor 2B (EIF2B), which isnecessary for protein synthesis, is a GTP exchange factor composedof five different subunits. The protein encoded by this gene is thefourth, or delta, subunit. Defects in this gene are a cause ofleukoencephalopathy with vanishing white matter (VWM) andovarioleukodystrophy. Multiple transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
References
Naukkarinen, J., et al. PLoS Genet. 6 (6), E1000976 (2010) :Wu, Y., et al. J. Hum. Genet. 54(2):74-77(2009)Horzinski, L., et al. PLoS ONE 4 (12), E8318 (2009) :Pronk, J., et al. Mult. Scler. 14(8):1123-1126(2008)Wong, S.S., et al. J. Child Neurol. 23(6):710-714(2008)
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