|Other Names||Homeobox protein Hox-D13, Homeobox protein Hox-4I, HOXD13, HOX4I|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:24789103). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).|
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This gene belongs to the homeobox family of genes. Thehomeobox genes encode a highly conserved family of transcriptionfactors that play an important role in morphogenesis in allmulticellular organisms. Mammals possess four similar homeobox geneclusters, HOXA, HOXB, HOXC and HOXD, located on differentchromosomes, consisting of 9 to 11 genes arranged in tandem. Thisgene is one of several homeobox HOXD genes located in a cluster onchromosome 2. Deletions that remove the entire HOXD gene cluster orthe 5' end of this cluster have been associated with severe limband genital abnormalities. Mutations in this particular gene causesynpolydactyly.
Sugie, Y., et al. Brain Dev. 32(5):356-361(2010)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Salsi, V., et al. Mol. Cell. Biol. 29(21):5775-5788(2009)Cantile, M., et al. Int. J. Cancer 125(7):1532-1541(2009)Wajid, M., et al. Clin. Genet. 76(3):300-302(2009)
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