|Other Names||Interferon regulatory factor 2, IRF-2, IRF2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.|
|Tissue Location||Expressed throughout the epithelium of the colon. Also expressed in lamina propria|
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IRF2 encodes interferon regulatory factor 2, a member ofthe interferon regulatory transcription factor (IRF) family. IRF2competitively inhibits the IRF1-mediated transcriptional activationof interferons alpha and beta, and presumably other genes thatemploy IRF1 for transcription activation. However, IRF2 alsofunctions as a transcriptional activator of histone H4. [providedby RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lace, M.J., et al. Virology 399(2):270-279(2010)Masumi, A., et al. Biochem. Biophys. Res. Commun. 391(4):1623-1628(2010)Daley, D., et al. Hum. Genet. 125(4):445-459(2009)Dhar, D., et al. PLoS ONE 4 (9), E7049 (2009) :
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