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GAD1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99259 |
|---|---|
| Clone Names | 80513156 |
| Gene ID | 2571 |
|---|---|
| Other Names | Glutamate decarboxylase 1, 67 kDa glutamic acid decarboxylase, GAD-67, Glutamate decarboxylase 67 kDa isoform, GAD1, GAD, GAD67 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GAD1 (HGNC:4092) |
|---|---|
| Synonyms | GAD, GAD67 |
| Function | Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor. |
| Tissue Location | [Isoform 1]: Expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes one of several forms of glutamic aciddecarboxylase, identified as a major autoantigen ininsulin-dependent diabetes. The enzyme encoded is responsible forcatalyzing the production of gamma-aminobutyric acid fromL-glutamic acid. A pathogenic role for this enzyme has beenidentified in the human pancreas since it has been identified as anautoantigen and an autoreactive T cell target in insulin-dependentdiabetes. This gene may also play a role in the stiff man syndrome.Deficiency in this enzyme has been shown to lead to pyridoxinedependency with seizures. Alternative splicing of this gene resultsin two products, the predominant 67-kD form and a less-frequent25-kD form.
References
Lanoue, A.C., et al. Exp. Neurol. 226(1):207-217(2010)Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :Terranova, C., et al. Alcohol 44(5):407-413(2010)Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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