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EAPII Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O95551
Clone Names 81020046
Peptide ID 81020046
Additional Information
Gene ID 51567
Other Names Tyrosyl-DNA phosphodiesterase 2, Tyr-DNA phosphodiesterase 2, hTDP2, 314-, 5'-tyrosyl-DNA phosphodiesterase, 5'-Tyr-DNA phosphodiesterase, ETS1-associated protein 2, ETS1-associated protein II, EAPII, TRAF and TNF receptor-associated protein, Tyrosyl-RNA phosphodiesterase, VPg unlinkase, TDP2, EAP2, TTRAP
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TDP2
Synonyms EAP2, TTRAP
Function DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'- tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'- tyrosyl-DNA phosphodiesterase in cells. Also acts as a 5'-tyrosyl- RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF- beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non- canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress.
Cellular Location Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene encodes a member of a superfamily of divalentcation-dependent phosphodiesterases. The encoded protein associateswith CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptorassociated factors (TRAFs), and inhibits nuclear factor-kappa-Bactivation. This protein has sequence and structural similaritieswith APE1 endonuclease, which is involved in both DNA repair andthe activation of transcription factors.


Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Wang, B.Y., et al. Mol. Biol. Rep. 37(6):2809-2816(2010)Iijima, M., et al. Neurology 73(17):1348-1352(2009)Cortes Ledesma, F., et al. Nature 461(7264):674-678(2009)Zhang, J.Q., et al. Biochem. Biophys. Res. Commun. 387(2):256-260(2009)

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$ 80.00
Cat# BP11233b
(40 western blots)
Availability: In Stock
Bulk Size
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