OR10J5 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NHC4 |
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Clone Names | 100120290 |
Gene ID | 127385 |
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Other Names | Olfactory receptor 10J5, Olfactory receptor OR1-28, OR10J5 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | OR10J5 (HGNC:14993) |
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Function | Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil. Its activation increases intracellular Ca(2+) (PubMed:25791473, PubMed:28842679). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway (By similarity). Acts also as a regulator of angiogenesis (PubMed:25791473). Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679). May be involved in sperm chemotaxis and motility (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in both the aorta, the coronary artery and umbilical vein endothelial cells (HUVECs) (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Olfactory receptors interact with odorant molecules in thenose, to initiate a neuronal response that triggers the perceptionof a smell. The olfactory receptor proteins are members of a largefamily of G-protein-coupled receptors (GPCR) arising from singlecoding-exon genes. Olfactory receptors share a 7-transmembranedomain structure with many neurotransmitter and hormone receptorsand are responsible for the recognition and G protein-mediatedtransduction of odorant signals. The olfactory receptor gene familyis the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism isindependent of other organisms.
References
Yang, Q., et al. BMC Med. Genet. 8 SUPPL 1, S12 (2007) :Malnic, B., et al. Proc. Natl. Acad. Sci. U.S.A. 101(8):2584-2589(2004)Gilad, Y., et al. Am. J. Hum. Genet. 73(3):489-501(2003)
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