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C6orf192 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6NT16 |
|---|---|
| Clone Names | 100126155 |
| Gene ID | 116843 |
|---|---|
| Other Names | MFS-type transporter SLC18B1, Solute carrier family 18 member B1, SLC18B1, C6orf192 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC18B1 {ECO:0000303|PubMed:25355561} |
|---|---|
| Synonyms | C6orf192 |
| Function | Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis. Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule (PubMed:25355561). Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation (PubMed:25355561) (By similarity). Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:D3Z5L6}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D4A9K4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D4A9K4}. Note=Colocalizes with VAMP3 and VAMP8 in mast cell secretory granules, which are distinct from histamine- and serotonin-containing granules (By similarity). Partly colocalizes with SYP in synaptic vesicles in hippocampal neurons. Colocalizes with SYP and VAMP2 in secretory vesicles of astrocytes (By similarity) {ECO:0000250|UniProtKB:D3Z5L6, ECO:0000250|UniProtKB:D4A9K4} |
| Tissue Location | Expressed in various tissues including lung, placenta, adrenal gland, liver, testis, and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein, which has high sequencesimilarity to rat, xenopus and zebrafish proteins. The proteinfunction is unknown.
References
Jacobsson, J.A., et al. J. Mol. Neurosci. 41(2):230-242(2010)Fu, G.K., et al. Genomics 84(1):205-210(2004)
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