|Other Names||Nuclear receptor subfamily 6 group A member 1, Germ cell nuclear factor, GCNF, hGCNF, Retinoid receptor-related testis-specific receptor, RTR, hRTR, NR6A1, GCNF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).|
|Tissue Location||Shows highest expression in the germ cells of the adult testis.|
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This gene encodes an orphan nuclear receptor which is amember of the nuclear hormone receptor family. Its expressionpattern suggests that it may be involved in neurogenesis and germcell development. The protein can homodimerize and bind DNA, but invivo targets have not been identified. The gene expresses at leastalternatively spliced transcript variants.
Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Rajkovic, M., et al. J. Biol. Chem. 279(50):52493-52499(2004)Yang, G., et al. Biol. Reprod. 68(5):1620-1630(2003)Lan, Z.J., et al. J. Biol. Chem. 277(52):50660-50667(2002)
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