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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   DRP-2 Monoclonal Antibody Blocking Peptide   

DRP-2 Monoclonal Antibody Blocking Peptide

Synthetic peptide

Product Information
Other Accession Q16555
Clone Names 70827103
Peptide ID 70827103
Additional Information
Target/Specificity The synthetic peptide sequence used to generate the antibody AM1131a was selected from the region of human DRP-2 Monoclonal. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas
Citations (0)

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DRP-2, also known as collapsin response mediator protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3? inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3? (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3? activity in these patients (5).


Hamajima,N., Gene 180 (1-2), 157-163 (1996)

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$ 80.00
Cat# BP1131a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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