|Other Names||Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, API4, IAP4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti- apoptotic effects when compared with the displayed wild-type isoform.|
|Cellular Location||Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export.|
|Tissue Location||Expressed only in fetal kidney and liver, and to lesser extent, lung and brain. Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines.|
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This gene is a member of the inhibitor of apoptosis (IAP)gene family, which encode negative regulatory proteins that preventapoptotic cell death. IAP family members usually contain multiplebaculovirus IAP repeat (BIR) domains, but this gene encodesproteins with only a single BIR domain. The encoded proteins alsolack a C-terminus RING finger domain. Gene expression is highduring fetal development and in most tumors yet low in adulttissues. Antisense transcripts are involved in the regulation ofthis gene's expression. At least four transcript variants encodingdistinct isoforms have been found for this gene, but thefull-length natures of only three of them have been determined.
Nabilsi, N.H., et al. J. Endocrinol. 207(2):237-243(2010)Valenzuela, M., et al. J. Infect. Dis. 202(7):1021-1030(2010)Yoon, S., et al. FEBS Lett. 584(18):4048-4052(2010)Ezponda, T., et al. Clin. Cancer Res. 16(16):4113-4125(2010)Sawai, K., et al. Oncol. Res. 18 (11-12), 541-547 (2010) :
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