|Other Names||Gamma-glutamylaminecyclotransferase, GGACT, AIG2-like domain-containing protein 1, Gamma-glutamylamine cyclotransferase, GGACT, A2LD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to degradation of proteins cross-linked by transglutaminases. Degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross- linked by transglutaminases. Catalyzes the formation of 5- oxoproline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma- glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene aids in the proteolyticdegradation of crosslinked fibrin by breaking down isodipeptideL-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrindegradation. The reaction catalyzed by the encodedgamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and afree alkylamine. Two transcript variants encoding the same proteinhave been found for this gene.
Oakley, A.J., et al. J. Biol. Chem. 285(13):9642-9648(2010)
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