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RLTPR Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6F5E8
Other Accession NP_001013860.1
Clone Names 100126187
Peptide ID 100126187
Additional Information
Gene ID 146206
Other Names Leucine-rich repeat-containing protein 16C, RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein, RLTPR, CARMIL2b, LRRC16C
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARMIL2 (HGNC:27089)
Function Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680).
Cellular Location Isoform 2: Cytoplasm Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle Note=Colocalizes to dynamic vimentin filaments both in the central cytoplasm and at leading edges of migrating cells (PubMed:26578515, PubMed:26466680, PubMed:19846667). Colocalizes with F-actin, Arp2/3 complex and cortactin to leading edge lamellipodia, ruffles and macropinosomes of migrating cells (PubMed:26578515).
Tissue Location Expressed in all tissues tested, including thymus, spleen, colon, leukocytes, peripheral blood, skin, skin keratinocytes and skin fibroblasts.
Research Areas
Citations (0)

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References

Liang, Y., et al. Mol. Biol. Cell 20(24):5290-5305(2009)Matsuzaka, Y., et al. Gene 343(2):291-304(2004)

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$ 80.00
Cat# BP11373b
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