|Other Names||GEM-interacting protein, GMIP, GMIP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates, in vitro and in vivo, the GTPase activity of RhoA.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ARHGAP family ofRho/Rac/Cdc42-like GTPase activating proteins. The encoded proteininteracts with the Ras-related protein Gem through its N-terminaldomain. Separately, it interacts with RhoA through a RhoGAP domain,and stimulates RhoA-dependent GTPase activity. Alternativelyspliced variants that encode different protein isoforms have beendescribed but their full-length nature has not been determined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Bosker, F.J., et al. Mol. Psychiatry (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Deng, Y.J., et al. Mol. Immunol. 43(9):1497-1507(2006)Tadokoro, K., et al. Neurogenetics 6(3):127-133(2005)
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