|Other Names||Transcription factor SOX-3, SOX3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).|
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This gene encodes a member of the SOX (SRY-relatedHMG-box) family of transcription factors involved in the regulationof embryonic development and in the determination of the cell fate.The encoded protein may act as a transcriptional regulator afterforming a protein complex with other proteins. Mutations in thisgene have been associated with X-linked mental retardation withgrowth hormone deficiency.
Dateki, S., et al. J. Clin. Endocrinol. Metab. 95(8):4043-4047(2010)Sato, Y., et al. Mol. Cell. Biochem. 337 (1-2), 267-275 (2010) :Mojsin, M., et al. Biochem. J. 425(1):107-116(2010)Bleyl, S.B., et al. Am. J. Med. Genet. A 143A (23), 2785-2795 (2007) :Krstic, A., et al. Arch. Biochem. Biophys. 467(2):163-173(2007)
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