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OSBP Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P22059
Clone Names 80917055
Peptide ID 80917055
Additional Information
Gene ID 5007
Other Names Oxysterol-binding protein 1, OSBP, OSBP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name OSBP (HGNC:8503)
Synonyms OSBP1
Function Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).
Cellular Location Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Predominantly cytosolic
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Oxysterol binding protein is an intracellular protein thatis believed to transport sterols from lysosomes to the nucleuswhere the sterol down-regulates the genes for the LDL receptor,HMG-CoA reductase, and HMG synthetase

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Ngo, M.H., et al. Biochem. J. 429(1):13-24(2010)Furuita, K., et al. J. Biol. Chem. 285(17):12961-12970(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Amako, Y., et al. J. Virol. 83(18):9237-9246(2009)

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$ 80.00
Cat# BP11453c
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