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OSBP Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P22059 |
|---|---|
| Clone Names | 80917055 |
| Gene ID | 5007 |
|---|---|
| Other Names | Oxysterol-binding protein 1, OSBP, OSBP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | OSBP (HGNC:8503) |
|---|---|
| Synonyms | OSBP1 |
| Function | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25- hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749). |
| Cellular Location | Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein Golgi apparatus, trans-Golgi network Note=Predominantly cytosolic. |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Oxysterol binding protein is an intracellular protein thatis believed to transport sterols from lysosomes to the nucleuswhere the sterol down-regulates the genes for the LDL receptor,HMG-CoA reductase, and HMG synthetase
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Ngo, M.H., et al. Biochem. J. 429(1):13-24(2010)Furuita, K., et al. J. Biol. Chem. 285(17):12961-12970(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Amako, Y., et al. J. Virol. 83(18):9237-9246(2009)
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