|Other Names||Oxysterol-binding protein 1, OSBP, OSBP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).|
|Cellular Location||Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Predominantly cytosolic|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Oxysterol binding protein is an intracellular protein thatis believed to transport sterols from lysosomes to the nucleuswhere the sterol down-regulates the genes for the LDL receptor,HMG-CoA reductase, and HMG synthetase
Bailey, S.D., et al. Diabetes Care (2010) In press :Ngo, M.H., et al. Biochem. J. 429(1):13-24(2010)Furuita, K., et al. J. Biol. Chem. 285(17):12961-12970(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Amako, Y., et al. J. Virol. 83(18):9237-9246(2009)
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