|Other Names||Oxysterol-binding protein 1, OSBP, OSBP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Note=When bound to oxysterols, translocates to the periphery of Golgi membranes|
|Tissue Location||Widely expressed.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Oxysterol binding protein is an intracellular protein thatis believed to transport sterols from lysosomes to the nucleuswhere the sterol down-regulates the genes for the LDL receptor,HMG-CoA reductase, and HMG synthetase
Bailey, S.D., et al. Diabetes Care (2010) In press :Ngo, M.H., et al. Biochem. J. 429(1):13-24(2010)Furuita, K., et al. J. Biol. Chem. 285(17):12961-12970(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Amako, Y., et al. J. Virol. 83(18):9237-9246(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.