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CPM Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P14384 |
|---|---|
| Clone Names | 80410140 |
| Gene ID | 1368 |
|---|---|
| Other Names | Carboxypeptidase M, CPM, CPM |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CPM |
|---|---|
| Function | Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a membrane-boundarginine/lysine carboxypeptidase. Its expression is associated withmonocyte to macrophage differentiation. This encoded proteincontains hydrophobic regions at the amino and carboxy termini andhas 6 potential asparagine-linked glycosylation sites. The activesite residues of carboxypeptidases A and B are conserved in thisprotein. Three alternatively spliced transcript variants encodingthe same protein have been described for this gene. [provided byRefSeq].
References
Rietschel, M., et al. Biol. Psychiatry 68(6):578-585(2010)Erickson-Johnson, M.R., et al. Mod. Pathol. 22(12):1541-1547(2009)Marquez-Curtis, L., et al. Stem Cells 26(5):1211-1220(2008)Zhang, X., et al. J. Biol. Chem. 283(12):7994-8004(2008)Elortza, F., et al. J. Proteome Res. 5(4):935-943(2006)
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