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ZC3H8 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N5P1
Clone Names 100126049
Peptide ID 100126049
Additional Information
Gene ID 84524
Other Names Zinc finger CCCH domain-containing protein 8, ZC3H8, ZC3HDC8
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZC3H8
Synonyms ZC3HDC8
Function Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Cellular Location Nucleus. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes
Research Areas
Citations (0)

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Background

Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

References

Lamesch, P., et al. Genomics 89(3):307-315(2007)Hwang, E.S., et al. Immunology 106(4):464-469(2002)Hwang, E.S., et al. J. Immunol. 169(1):248-253(2002)

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$ 80.00
Cat# BP11463a
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