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NGFB Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01138 |
|---|---|
| Clone Names | 71211139 |
| Gene ID | 4803 |
|---|---|
| Other Names | Beta-nerve growth factor, Beta-NGF, NGF, NGFB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NGF |
|---|---|
| Synonyms | NGFB |
| Function | Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:20978020) (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). |
| Cellular Location | Secreted. Endosome lumen {ECO:0000250|UniProtKB:P01139}. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR {ECO:0000250|UniProtKB:P01139} |
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Background
NGFB is a member of the NGF-beta family and homodimerizes and is incorporated into alarger complex. This protein has nerve growth stimulating activityand the complex is involved in the regulation of growth and thedifferentiation of sympathetic and certain sensory neurons.Mutations in this gene have been associated with hereditary sensoryand autonomic neuropathy, type 5 (HSAN5), and dysregulation of thisgene's expression is associated with allergic rhinitis. [providedby RefSeq].
References
Li, C., et al. Clin. Chim. Acta 411 (19-20), 1482-1486 (2010) :Houeland, G., et al. J. Neurosci. 30(39):13089-13094(2010)Shieh, K.R., et al. Neurogastroenterol. Motil. 22(9):971-977(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Sornelli, F., et al. Mol. Vis. 16, 1439-1447 (2010) :
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