|Other Names||Beta-nerve growth factor, Beta-NGF, NGF, NGFB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).|
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NGFB is a member of the NGF-beta family and homodimerizes and is incorporated into alarger complex. This protein has nerve growth stimulating activityand the complex is involved in the regulation of growth and thedifferentiation of sympathetic and certain sensory neurons.Mutations in this gene have been associated with hereditary sensoryand autonomic neuropathy, type 5 (HSAN5), and dysregulation of thisgene's expression is associated with allergic rhinitis. [providedby RefSeq].
Li, C., et al. Clin. Chim. Acta 411 (19-20), 1482-1486 (2010) :Houeland, G., et al. J. Neurosci. 30(39):13089-13094(2010)Shieh, K.R., et al. Neurogastroenterol. Motil. 22(9):971-977(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Sornelli, F., et al. Mol. Vis. 16, 1439-1447 (2010) :
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