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NTHL1 Antibody (Center R103) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P78549
Clone Names 80522073
Peptide ID 80522073
Additional Information
Gene ID 4913
Other Names Endonuclease III-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03183}, hNTH1, 322- {ECO:0000255|HAMAP-Rule:MF_03183}, 429918 {ECO:0000255|HAMAP-Rule:MF_03183}, Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase {ECO:0000255|HAMAP-Rule:MF_03183}, DNA glycoslyase/AP lyase {ECO:0000255|HAMAP-Rule:MF_03183}, NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}, NTH1, OCTS3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}
Synonyms NTH1, OCTS3
Function Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Cellular Location Nucleus. Mitochondrion.
Tissue Location Widely expressed with highest levels in heart and lowest levels in lung and liver.
Research Areas
Citations (0)

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The protein encoded by this gene is a DNA N-glycosylase ofthe endonuclease III family. Like a similar protein in E. coli, theencoded protein has DNA glycosylase activity on DNA substratescontaining oxidized pyrimidine residues and hasapurinic/apyrimidinic lyase activity.


Wang, W., et al. Nucleic Acids Res. (2010) In press :Arora, M., et al. Leukemia 24(8):1470-1475(2010)Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Goto, M., et al. Carcinogenesis 30(8):1345-1352(2009)

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$ 80.00
Cat# BP11554c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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