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NTHL1 Antibody (Center R103) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P78549
Clone Names 80522073
Peptide ID 80522073
Additional Information
Gene ID 4913
Other Names Endonuclease III-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03183}, hNTH1, 322- {ECO:0000255|HAMAP-Rule:MF_03183}, 429918 {ECO:0000255|HAMAP-Rule:MF_03183}, Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase {ECO:0000255|HAMAP-Rule:MF_03183}, DNA glycoslyase/AP lyase {ECO:0000255|HAMAP-Rule:MF_03183}, NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}, NTH1, OCTS3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTHL1 {ECO:0000255|HAMAP-Rule:MF_03183}
Synonyms NTH1, OCTS3
Function Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Cellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:12531031, ECO:0000269|PubMed:9611236}. Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03183, ECO:0000269|PubMed:9611236}
Tissue Location Widely expressed with highest levels in heart and lowest levels in lung and liver.
Research Areas
Citations (0)

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The protein encoded by this gene is a DNA N-glycosylase ofthe endonuclease III family. Like a similar protein in E. coli, theencoded protein has DNA glycosylase activity on DNA substratescontaining oxidized pyrimidine residues and hasapurinic/apyrimidinic lyase activity.


Wang, W., et al. Nucleic Acids Res. (2010) In press :Arora, M., et al. Leukemia 24(8):1470-1475(2010)Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Goto, M., et al. Carcinogenesis 30(8):1345-1352(2009)

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$ 80.00
Cat# BP11554c
Availability: In Stock
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