|Other Names||Mastermind-like protein 1, Mam-1, MAML1 (HGNC:13632)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.|
|Cellular Location||Nucleus speckle. Note=Nuclear, in a punctate manner|
|Tissue Location||Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen|
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This protein is the human homolog of mastermind, aDrosophila protein that plays a role in the Notch signaling pathwayinvolved in cell-fate determination. There is in vitro evidencethat the human homolog forms a complex with the intracellularportion of human Notch receptors and can increase expression of aNotch-induced gene. This evidence supports its proposed function asa transcriptional co-activator in the Notch signaling pathway.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lindberg, M.J., et al. FASEB J. 24(7):2396-2404(2010)Hao, L., et al. Oncogene 29(2):201-213(2010)Saint Just Ribeiro, M., et al. Curr. Protein Pept. Sci. 10(6):570-576(2009)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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