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MITF Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O75030
Clone Names 80821074
Peptide ID 80821074
Additional Information
Gene ID 4286
Other Names Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32, MITF, BHLHE32
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BHLHE32
Function Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'- CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Cellular Location Nucleus.
Tissue Location Isoform M is exclusively expressed in melanocytes and melanoma cells. Isoform A and isoform H are widely expressed in many cell types including melanocytes and retinal pigment epithelium (RPE). Isoform C is expressed in many cell types including RPE but not in melanocyte-lineage cells. Isoform Mdel is widely expressed in melanocytes, melanoma cell lines and tissues, but almost undetectable in non-melanoma cell lines
Research Areas
Citations (0)

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This gene encodes a transcription factor that containsboth basic helix-loop-helix and leucine zipper structural features.It regulates the differentiation and development of melanocytesretinal pigment epithelium and is also responsible for pigmentcell-specific transcription of the melanogenesis enzyme genes.Heterozygous mutations in the this gene cause auditory-pigmentarysyndromes, such as Waardenburg syndrome type 2 and Tietz syndrome.Alternatively spliced transcript variants encoding differentisoforms have been identified.


Wang, Y., et al. BMC Med 8, 14 (2010) :Shiohara, M., et al. Int J Lab Hematol 31(2):215-226(2009)Hershey, C.L., et al. Gene 347(1):73-82(2005)Miller, A.J., et al. J. Biol. Chem. 280(1):146-155(2005)Shibahara, S., et al. J. Investig. Dermatol. Symp. Proc. 6(1):99-104(2001)

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$ 80.00
Cat# BP11559a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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